Further, in the context of cardiovascular disease (CVD), RBC imbalances in arginase and NO synthase suggest that increased RBC arginase-1 activity decreases NO bioavailability, superoxide production, endothelial dysfunction, and enhances post-ischemic cardiac failure (Yang et al., 2018; Mahdi et al., 2019; Pernow et al., 2019). The gene discussed is ARG1; the disease is endothelial dysfunction.