SLC12A3 and pseudohypoaldosteronism type 2: In mice and humans, mutations in WNK4 that cause kinase overexpression are the cause of Familial Hyperkalemic Hypertension (FHHt), a disease that is mainly the consequence of the upregulation of NCC activity (Wilson et al., 2001; Lalioti et al., 2006; Yang et al., 2007; Shibata et al., 2013).