SLC12A3 and Gitelman syndrome: When this mechanism is broken, alterations in K+ homeostasis occur, like it is observed in Gitelman’s syndrome, caused by loss of function of NCC, or in Familial Hyperkalemic Hypertension (FHHt), which appears to be mainly caused by overactivation of NCC (Wilson et al., 2001; Lalioti et al., 2006).