Although WNT5A was reported to be able to regulate cell proliferation and adipogenesis via MAPK, data on the relationships between WNT5A and SFRP5 in humans with obesity are limited and inconsistent (Hu W. et al., 2013; Lu et al., 2013; Miyoshi et al., 2014; Ji et al., 2017; Tang et al., 2018). Here, WNT5A is linked to obesity due to melanocortin 4 receptor deficiency.