Hyperleptinemia is positively correlated with obesity and metabolic dysfunction, decreases food intake, increases energy expenditure and insulin resistance (Rosenbaum and Leibel, 1999; Ahima et al., 2000; Schwartz et al., 2000; Hafizuallah, 2006; Al-Amodi et al., 2018). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.