Besides its role in adipogenesis and energy metabolism (Bozaoglu et al., 2007; Goralski et al., 2007; Ernst et al., 2010; Roman et al., 2012), recent studies reported a key role for chemerin in the pathologenesis of cardiovascular diseases, including coronary heart disease (Kaur et al., 2018). This evidence concerns the gene RARRES2 and cardiovascular disorder.