The association of leptin with amylin, a peptide hormone released with insulin by pancreatic beta cells which modulate glucose and energy homeostasis, showed enthusiastic results, predominantly mediated by decreased feeding and increased central leptin sensitivity in diet-induced obesity (Roth et al., 2008; Trevaskis et al., 2010). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.