FN1 and ischemia: Derived from the observed close regional association of collagen IV and fibronectin – and considering their primary locations with reference to the basement membrane and the adjoined ECM (del Zoppo and Milner, 2006; Singh et al., 2010; Gatseva et al., 2019) – this study provides robust evidence for an ischemia-induced critical affection of the NMZ.