Reversal of these effects by reconstitution of NKLAM–/– mice with WT bone marrow would confirm the role of NKLAM+ hematopoietic cells in anti-tumor immunity; adoptive transfer of WT NK cells into NKLAM–/– mice would confirm the role of NKLAM+ NK cells in controlling tumor spread. The gene discussed is RNF19B; the disease is neoplasm.