KCNQ2 and developmental and epileptic encephalopathy: During the last decade, an emerging number of studies pointed out that severe disruption of the function of Kv7.2, Kv7.3, and Kv7.5 subunits due to de pathogenic variants in the encoding gene leads to developmental and epileptic encephalopathy (DEE; Weckhuysen et al., 2012; Lehman et al., 2017; Lauritano et al., 2019).