By contrast, only a handful of DEE patients with pathogenic variants in KCNQ3 or KCNQ5 have been described (Rauch et al., 2012; Epi4k Consortium et al., 2013; Lehman et al., 2017; Ambrosino et al., 2018; Kothur et al., 2018; Lauritano et al., 2019; Rosti et al., 2019; Sands et al., 2019). The gene discussed is KCNQ3; the disease is developmental and epileptic encephalopathy.