To date, malfunction of syntaxin-1A itself is not known to be directly associated with neurodevelopmental disorders, however, pathogenic variants in the gene that encodes for the binding partner syntaxin binding protein 1 (STXBP1) are known to cause several DEE forms including a similar phenotype to KCNQ2-encephalopathy (Stamberger et al., 2016). Here, STXBP1 is linked to Encephalopathy.