The cytokines of IL-4, IL-5, and IL-13 produced by Th2 cells are deeply involved in IgE synthesis, eosinophil activation, mucus secretion, and airway remodeling during the pathogenesis of asthma (Manka and Wechsler, 2018; Ramsahai et al., 2019). The gene discussed is IGHE; the disease is asthma.