HIF1A and preeclampsia: In early-onset preeclampsia, both HIF1A and FIH1 deSUMOylation by SENP3 was significantly elevated in the human placenta, and this partly contributes to increased HIF1A activity and stability in physiological and pathological conditions (Bhattacharjee et al., 2016; Sallais et al., 2017).