Taken together, LncRNAs act as a bridge between high glucose (HG) and lipotoxicity induced by cholesterol accumulation in GEnCs, and an understanding of the role of glucolipid metabolism disorders on the expression of ABCA1 and cholesterol accumulation in GEnCs via a regulatory pathway involving LncRNAs may uncover the underlying mechanisms of the pathogenesis of DN. This evidence concerns the gene ABCA1 and liver dysplastic nodule.