Meanwhile, SIRT1 has been reported to exert a protective role in myocardia injury (Fu et al., 2017), whereas our findings demonstrated that SIRT1 expression was repressed in myocardial tissue after MI/R injury, whereby its elevation reduced the extent of MI/R injury by enhancing cardiomyocyte viability and diminishing ferroptosis-induced cell death. Here, SIRT1 is linked to myocardial infarction.