Most recently, PIO has been reported to reverse pulmonary arterial hypertension, another type of PH, and reverse vascular remodeling via fatty acid oxidation (Legchenko et al., 2018), inhibiting transforming growth factor-β (TGFβ1) signaling (Calvier et al., 2019) and 5-HT receptor signaling (Liu et al., 2012b). The gene discussed is TGFB1; the disease is pulmonary arterial hypertension.