Additionally, of 101 genes reportedly associated with PCD or human congenital heart disease with extracardiac and laterality defects, dysregulation of 7, 29, and 25 genes, respectively, was seen in human BA liver, Man1a2–/– liver and Man1a2–/– lung (Supplementary Tables 9–11; De Luca et al., 2010; Shiraishi and Ichikawa, 2012; Andersen et al., 2014; Bergström et al., 2012). Here, MAN1A2 is linked to primary ciliary dyskinesia.