The two top-ranked intronic SNPs rs12131109 and rs7531715 in LD (r2 > 0.8) in the MAN1A2 gene demonstrated significantly higher MAF in the discovery cohort (p = 2.14E-04 and p = 1.89E-04, respectively), replication cohort (p = 9.73E-04 and p = 9.73E-04, respectively) and in 89 combined BA cases (4.59E-08 and p = 4.59E-08, respectively) (Table 1). Here, MAN1A2 is linked to breast angiosarcoma.