The human BA and Man1a2–/– transcriptomes also demonstrate dysregulated ciliary genes, many of which cause human PCD, or congenital heart disease with laterality and/or extracardiac defects (De Luca et al., 2010; Shiraishi and Ichikawa, 2012; Andersen et al., 2014; Bergström et al., 2012). Here, CFB is linked to congenital heart disease.