OGT and hypertensive disorder: O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) possesses the ability to accelerate hypertension-associated proteinuria, a detrimental factor leading to CKD, and moreover, the O-linked-β-N-acetylglucosamine (O-GlcNAcylation) pathway has been reported to be implicated with vascular dysfunction (Silva-Aguiar et al., 2018).