Inactivation of GSK-3β phosphorylation facilitates the nuclear localization of β-catenin, leading to the activation of GSK/β-catenin signaling pathway, increasing the expression of snail, ZEB1 and Twist, thereby promoting tumor EMT and metastasis (Wang et al., 2018; Zhang et al., 2018a). The gene discussed is SNAI1; the disease is neoplasm.