Surprisingly, the YZT-treated P301S (Figure 7A) and 3XTg-AD (Figure 7B) brain lysates illustrated a significant decrease in polyubiquitin proteins compared to the Tg-vehicle group, demonstrating YZT degrades the insoluble phospho tau via UPS both in vitro and in vivo. Further we also evaluated the other degradative pathway proteins in YZT-treated mice brain lysates compared to the Tg-vehicle group, we did not discover any substantial alterations in autophagy proteins and kinases (Supplementary Figures S5A,B) involved in tau degradation. The gene discussed is MAPT; the disease is Alzheimer disease.