The PHF1-positive neuron load in the brain slice of 3XTg-AD mice demonstrated that YZT treatment at doses of 1, 2, and 4 g/kg/d decreased PHF1 positive cell count dose dependent in CA2, CA3 hippocampal region by 44, 55, and 70%, respectively (p < 0.05) (Figures 3C,D). This evidence concerns the gene PHF1 and Alzheimer disease.