However, pathological alterations including overexpression or mutations in the tyrosine-kinase site to HER-1 and/or HER-2 are directly associated with the development of different types of human cancer (Hynes and Lane, 2005; González and Lage, 2007; Ross et al., 2016; Sigismund et al., 2018; Thomas and Weihua, 2019). This evidence concerns the gene EGFR and cancer.