We also observed significant increase in the production of ROS in the colons of IL-4Rα-/- colitis mice compared to WT colitis mice, (Figure 5B; 0.8 × 108 ± 0.1 × 108 RLU/mg protein in WT colitis, 10.3 × 108 ± 3.2 × 108 RLU/mg protein in IL-4Rα-/- colitis; p < 0.01). This evidence concerns the gene IL4R and colitis.