IL4R and colitis: The production of ROS was significantly increased in the colons of IL-4Rα-/- normal mice compared with WT normal mice (Figure 5B; 0.7 × 108 ± 0.1 × 108 RLU/mg protein in WT normal, 9.8 × 108 ± 0.8 × 108 RLU/mg protein in IL-4Rα-/- colitis; p < 0.05).