IL4R and colonic neoplasm: IL-4Rα was strongly expressed in the colonic tumors of murine colitis-associated cancer (CAC) model in WT mice, and the number and size of colonic tumors were significantly reduced in IL-4Rα-/- CAC mice through the suppression of epithelial tumor proliferation due to lack of IL-4Rα-/- signaling, however there was no information about the inflammation in this previous study (Koller et al., 2010).