The most common side effects were fatigue (11 patients, 37.9%), hand-foot syndrome (10 patients, 34.5%), change of hair color (10 patients, 34.5%), elevated alanine transaminase (ALT)/aspartate transaminase (AST) (10 patients, 34.5%), hypertension (seven patients, 24.1%), neutropenia (three patients, 10.3%), anemia (three patients, 10.3%), thrombocytopenia (two patients, 6.9%), and diarrhea (one patient, 3.4%). This evidence concerns the gene GPT and Hand-foot syndrome.