LRRK2 and Parkinson disease: More than 40 mutations in LRRK2 have been found, of which eight (N1437H, R1441C/G/H/S, Y1699C, G2019S, and I2020T) cause PD and A419V, R1628P, M1646T and G2385R are considered risk factors for PD (Heckman et al., 2013; Li et al., 2015; Mata et al., 2017; Alessi and Sammler, 2018; De Wit et al., 2018).