PIK3R1 and Alzheimer disease: As shown in Figure 7, MAPT, PIK3R1, CASP8, and DAPK1 were significantly increased (p < 0.05, Figures 7A–D), but MAPK1 and CYCS were significantly decreased (p < 0.05, Figures 7E,F) in the AD group of the GSE5281 dataset.