Numerous studies have demonstrated that these toxic structures do not act independently and that rather, the neurodegenerative process in AD depends on the interaction between both Aβ and tau (Götz et al., 2001; Lewis et al., 2001; Rapoport et al., 2002; King et al., 2006; Roberson et al., 2007; Hurtado et al., 2010; Ittner et al., 2010; Vossel et al., 2010; Nussbaum et al., 2012; Zempel et al., 2013; Wang et al., 2016). Here, MAPT is linked to Alzheimer disease.