IAPP and type 2 diabetes mellitus: We hypothesize that amylin protofibrils might confer resistance against multiple stressors in β-cells in the pancreas, which might be transgenerationally transmitted via the germ line to offspring, the absence of which might lead to type 1 DM (T1DM), and where T2DM in parents might promote amylin evolvability, while T1DM in parents might increase T1DM in offspring.