Interestingly, we found the combination of progerin and oxidative stress to synergistically increase oxidative damage selectively in HD neurons beyond what was seen with either insult alone (post-test vs. progerin + H2O2 same genotype Hu18/18 nGFP p = 0.0733, progerin p > 0.9999, H2O2p > 0.9999; Hu97/18 nGFP p < 0.0001; progerin p = 0.0069, H2O2p = 0.0500). The gene discussed is LMNA; the disease is Huntington disease.