We found a strong trend toward a selective increase in oxidative DNA damage in HD, but not control, neurons when treated with progerin (Figures 5B,C, Supplementary Figures S4, S5, treatment p < 0.0001, genotype p < 0.0001, post-test vs. nGFP same genotype Hu18/18 progerin p = 0.8699; Hu97/18 progerin p = 0.1088. This evidence concerns the gene LMNA and Huntington disease.