HSPB1 and cancer: The HspB1 chaperone (also known as Hsp27 in humans and Hsp25 in rodents) is a stress-responsive chaperone which both facilitates folding and acts as an antioxidant; the secretion of this chaperone under various cellular conditions – the majority of which are cancer-related – has been nicely summarized in Reddy et al. (2018).