Adding to this complexity, in the 5xFAD (familial Alzheimer’s disease) model mouse background, clusterin null mice showed fewer Abeta plaques and cognitive performance deficits compared to clusterin-expressing mice at 5 months of age, though the differences disappeared by 10 months, suggesting that clusterin expression is only required for early toxicity (Oh et al., 2019). Here, CLU is linked to familial Alzheimer disease.