HSPB1 and neurodegenerative disease: Evidence of the involvement of sHSPs in neurodegenerative disease comes from studies of human mutations; for example, mutations in the three family members most abundant in brain, HspB1, HspB3, and HspB8, have been implicated in certain forms of Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy (Muranova et al., 2019; Vendredy et al., 2020).