Moreover, two stress-based rodent models of PTSD-like behaviors (though rodent models of PTSD are still evolving and emerging), one which subjected male rats to a single prolonged stressor consisting of 2-h restraint and 20 min forced swim (Wang et al., 2019), and another which subjected adolescent rats to inescapable electric foot shocks (Li et al., 2015) both resulted in increased CRF-R1 in the PFC. This evidence concerns the gene CRHR1 and post-traumatic stress disorder.