Post mortem tissue from subjects with MDD exhibit a significant reduction in the expression of SST mRNA (measured by qPCR) and SST precursor protein (measured by western blot for prepro-SST) in the dorsolateral PFC (Sibille et al., 2011) and subgenual anterior cingulate cortex (Tripp et al., 2011). This evidence concerns the gene SST and major depressive disorder.