Further, Adcy8 codes for a protein kinase that has been repeatedly implicated in anxiety-like behavior, synaptic plasticity, and mood disorders (Schaefer et al., 2000; de Mooij-van Malsen et al., 2009; Bernabucci and Zhuo, 2016; Tanaka et al., 2019). This evidence concerns the gene ADCY8 and mood disorder.