Also, activation of α7nAChR by a pre-treatment with a positive allosteric modulator (PAM) reduced LPS-induced expression of the pro-inflammatory markers IL-1β, TNF-α, and the microglial activation marker cluster of differentiation 11b (CD11b) in the hippocampus and prefrontal cortex (PFC) of mice, and even blocked LPS-induced anxiety-like behaviors (Abbas et al., 2017; Alzarea and Rahman, 2019). This evidence concerns the gene CHRNA7 and Anxiety.