In another study, long-term treatment of aged 3xTg-AD mice with the selective α7nAChR agonist, A-582941 (12 mg/kg/day, for 3 months, from 15 to 18 months of age), completely restored cognition in 3xTg-AD mice to the level of that in age-matched non-transgenic controls (Medeiros et al., 2014). The gene discussed is CHRNA7; the disease is Alzheimer disease.