NFE2L2 and hereditary elliptocytosis: Our results suggest that: (i) there is a decrease in H2S production and bacteria associated with H2S production in the blood of HE patients; (ii) H2S attenuates NH4Cl-induced cytotoxicity, OxS, and apoptosis in primary rat astrocytes; and (iii) the Nrf2/ARE signaling pathway mediates the cytoprotection of H2S against NH4Cl-induced neurotoxicity.