MS patients showed an intrathecal production of IgG, IgM, and IgA (Lolli et al., 1989); about 95% of the MS patients displayed IgG OCBs (Link, 1978; Villar et al., 2005), and around 40% also showed intrathecal IgM production (Villar et al., 2005), while CSF IgA synthesis was only occasionally observed (in 13% of cases) (Link and Müller, 1971; Leary et al., 2000). The gene discussed is CD40LG; the disease is myeloid sarcoma.