Therefore, although the correlations that we identified in the CSF at time of diagnosis between all these mediators and IgM were modest and need to be validated in a larger and independent MS population, it might be hypothesized that IgM could possibly reflect the interactions between innate and adaptive humoral immune responses, as previously suggested (Boes, 2000; Villar et al., 2010). Here, CD40LG is linked to myeloid sarcoma.