CD40LG and myeloid sarcoma: Although there were no significant correlations between the CSF IgM levels and WMLs and CL number at diagnosis, when MS patients were stratified according to the CL load, we found a trend to increase of CSF IgM levels that were almost twice higher in MS patients with CLs ≥ 4 compared to MS patients with CLs < 4 (fold change = 1.74, p = 0.072; Figure 2B).