Of further interest are the number of recent studies which suggest the nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is activated by glycolytic enzymes (Hughes and O’Neill, 2018); activation of the NLRP3 inflammasome has been demonstrated to contribute to AD pathology (Heneka et al., 2013; Venegas et al., 2017; Ising et al., 2019). Here, NLRP3 is linked to Alzheimer disease.