It may be possible that genes involved in PDGFR, EGFR, NTRK3, and mTOR signaling and/or genetic variations in PIK3CA, AKT3, RHEB, MTOR, TSC1/2, SLC35A2, TSC2, DEPDC5 genes may have contributed to the differential regulation of GABAergic activity in EO and LO patients with FCD. The gene discussed is PIK3CA; the disease is fleck corneal dystrophy.