Vitamins B1 and B12 upregulate brain-derived neurotrophic factor (BDNF) expression and its downstream PI3K/Akt signaling pathway through the MALAT1/miR-1 axis, thereby inhibiting neuronal apoptosis and reducing nerve damage in cerebral palsy rat models (Li et al., 2019). This evidence concerns the gene AKT1 and cerebral palsy.