In Alzheimer’s Disease models based on NGF-stimulated PC12 cells and primary cerebral cortex neurons, MALAT1 inhibits neuron apoptosis and neuroinflammation, while it stimulates neurite outgrowth via miR-125b-regulated PGTS2, CKD5, and FOXA1 expression (Ma et al., 2019). Here, MALAT1 is linked to early-onset autosomal dominant Alzheimer disease.