TSPO and myeloid sarcoma: Datta et al. (2017) detected that radioligand uptake predominantly occurred in the thalamus and that MS patients showed higher radioligand binding to TSPO in this region than healthy controls. Furthermore, an increase in radioligand uptake was identified in NAWM, compared to healthy WM (Datta et al., 2017), which is supported by Van Wageningen et al. (2019) who observed a decrease in the homeostatic gene expression of P2RY12 and TMEM119 in microglia, suggesting a shift toward reactive microglia.