This theoretical study of nNOS SUMO-ylation provides a new pathological outlook to nNOS inhibition in cognitive decline and myopathies (Kelley et al., 2009, 2011; Ito et al., 2013; Pavesi et al., 2013; Baldelli et al., 2014; James et al., 2015). Here, NOS1 is linked to myopathy.