Several studies claim that CXCR2 could augment AD pathology in mouse models and that deficiency in CXCR2 decreases amyloid-beta deposition (Xia and Hyman, 2002; Bakshi et al., 2011; Veenstra and Ransohoff, 2012; Ryu et al., 2015). This evidence concerns the gene CXCR2 and Alzheimer disease.