NOX4 and brain infarction: In particular, iNOS is expressed in infiltrating neutrophils and endothelial cells 6–96 h after MCAO in rats and in human cerebral infarcts (Forster et al., 1999), adding NO fuel to the fire and synergizing oxidatively with superoxide emanating from neutrophil NOX2 (Tang et al., 2011) and endothelial NOX4.