CYBB and brain infarction: NOX1, NOX2 and NOX4 are the main brain isoforms, and mice with genetic deletion of the gp91phox catalytic unit of NOX2 exhibited reduced brain infarction after tMCAO, even if neutrophil NOX2 was rescued with a bone marrow transplant (Walder et al., 1997; Tang et al., 2011).