Lee and coworkers explored the CRISPR-mediated disruption of metabotropic glutamate receptor 5 (mGluR5) as a mean of counteracting FXS by delivering RNPs SpCas9 or Cas12a targeting the mGluR5 to the striatum of Fmr1-knockout mice (a mouse model of FXS) (Lee B. et al., 2018). Here, FMR1 is linked to fragile X syndrome.