Several lines of evidence associate epigenome modifications to ALS development, with alterations in DNA methylation and DNA-(cytosine-5)- methyltransferase (DNMT) enzyme activity, as well as alterations to the balance between histone acetylation and deacetylation observed in blood and post-mortem neural tissue from patients with ALS and in different experimental models (Paez-Colasante et al., 2015; Dolinar et al., 2018; Bennett et al., 2019). Here, DNMT1 is linked to amyotrophic lateral sclerosis.