In addition, although controversial, several results reported that TDP-43 aggregates occur in the vast majority of SOD1- and FUS-negative FALS patients, but not in SOD1/FUS mutation carriers, suggesting that mutant TDP-43 may cause ALS through specific pathways of inclusion formation that are distinct from those that underlie SALS or other FALS-associated mutations, opening the way to the development of specific therapeutic approaches that take into account these selective modifications (Farrawell et al., 2015; Jeon et al., 2019). Here, SOD1 is linked to amyotrophic lateral sclerosis.