Such aggregates are present in almost all cases of ALS, including SALS and FALS patients with pathogenic variants of C9ORF72 (Mackenzie et al., 2007; Chew et al., 2015), as well as in other neurodegenerative disorders, including FTD, Parkinson’s and Alzheimer’s disease (Amador-Ortiz et al., 2007; Umoh et al., 2018). The gene discussed is C9orf72; the disease is Parkinson disease.