Another interesting example regards a newly identified ALS gene, KIF5A. In fact, missense mutations in the N-terminal motor domain of this gene are known to cause hereditary spastic paraplegia and Charcot–Marie–Tooth disease type 2, while ALS-associated mutations are predominantly located at the C-terminal tail domain (Brenner et al., 2018; Nicolas et al., 2018). Here, KIF5A is linked to amyotrophic lateral sclerosis.