Considering the neuronal developmental phenotypes, including intellectual disability exhibited by patients with the CTBP1 p.R342W mutation and adherence phenotypes of the mutant cells observed while differentiating NSC to neurons (not shown), we pursued RNA sequencing and observed the suppression of genes involved in neuronal development and cell adhesion (Figure 4A and Supplementary Table 1). The gene discussed is CTBP1; the disease is Intellectual disability.