ANXA5 and age-related macular degeneration: Circulating autoantibodies (AAbs) directed against targets implicated in autophagy control, i.e.: anti-S100A9 AAbs, anti-ANXA5 AAbs, and anti-HSPA8, A9 and B4 AAbs, can contribute to AMD pathogenesis directly, compromising an autophagy-mediated mechanism, and indirectly, activating downstream of the inflammasomes (Iannaccone et al., 2015[54]).