Considering the time of infection (≤30 days versus >30 days), gender (male versus female), and histopathological tissue response (granulomas versus nongranuloma reaction and presence versus absence of ulcer), no significant difference was observed in the cellular densities of IL-1β, IL-18, and caspase-1 (p > 0.05). This evidence concerns the gene IL18 and Granuloma.