Considering the time of infection (≤30 days versus >30 days), gender (male versus female), and histopathological tissue response (granulomas versus nongranuloma reaction and presence versus absence of ulcer), no significant difference was observed in the cellular densities of IL-1β, IL-18, and caspase-1 (p > 0.05). The gene discussed is CASP1; the disease is Granuloma.