However, the group that had been pretreated with coadministered TP and Ki20227 showed promotion of upregulated expressions of NeuN, PD95, and SYN in the penumbra area of the cerebral ischemia, thus, evidencing the protectiveness of the pretreated agents against neuronal and synaptic damages. The gene discussed is RBFOX3; the disease is Cerebral ischemia.