TJP1 and serum lipopolysaccharide activity: The occludin and ZO-1 decreased in the cortices of endotoxemia mice compared to the control, while isoorientin (25 and 50 mg/kg) and LiCl (100 mg/kg) increased the expressions of occludin and ZO-1 in endotoxemia mice (Figure 5(a)), which meant preventive effects of isoorientin on the disruption of BBB.