Although the impact of sepsis on autoimmunity is understudied, the known influences of sepsis on CD4 T cells and their environment provided a pivotal framework to begin interrogating this relationship (Cabrera-Perez et al., 2016; Cabrera-Perez et al., 2017; Cabrera-Perez et al., 2014; Cabrera-Perez et al., 2015; Chen et al., 2017; Hotchkiss et al., 2001). Here, CD4 is linked to Sepsis.