Characterization of how sepsis also influences cells that function to suppress autoimmune disease, such as CD4 Tregs which are more resistant to sepsis-induced numerical loss than other CD4 T cell subsets (Cavassani et al., 2010; Monneret et al., 2003; Scumpia et al., 2006; Sharma et al., 2015), would also provide an interesting angle for interrogating the immunoparalysis state. Here, CD4 is linked to autoimmune disease.