With regard to the critical role for CD4 T cells in EAE disease, the sepsis-induced lymphopenic state is known to impact both naive and memory CD4 T cells (Cabrera-Perez et al., 2016; Cabrera-Perez et al., 2015; Chen et al., 2017; Jensen et al., 2018a; Sjaastad et al., 2020b). This evidence concerns the gene CD4 and Sepsis.