CD4 and Sepsis: In contrast, the 2D2 cells in the post-transfer experiments were only influenced by the sepsis-induced changes in the environment, such as reduced DC function (Strother et al., 2016), reduced capacity to traffic across endothelium (Danahy et al., 2017), and alterations in the proportion of regulatory CD4 and CD8 T cells (Sharma et al., 2015; Sinha et al., 2015).