In preclinical models, ASCL1 was demonstrated as a pivot in the NE differentiation and carcinogenesis of SCLC by direct regulation of oncogenes including MYCL1, RET, SOX2, BCL2 and NFIB and a multitude of members in NOTCH signaling pathway such as DLL3.8, 9. This evidence concerns the gene ASCL1 and small cell lung carcinoma.