It is observed in the in vivo experiments that the tumour formation and growth was increased by adding with CX3CL1 compared to control mice (Figure 4A‐C), and immunohistochemistry results showed that p‐cortactin 421 and MMP‐3 were up‐regulated in CX3CL1 group (Figure 4D). Here, CX3CL1 is linked to neoplasm.