Strikingly, all the tested CRC cell lines had highly activated signaling of oncogenic transcription and translation reprograming as evidenced by increased levels of β-catenin, c-Myc, NF-κB, and p-NF-κB, the signaling nodes (mTOR, Raptor, Rictor, p-S6, p-4EBP), and eIF4F. The gene discussed is EIF4E; the disease is colorectal carcinoma.