VEGFA and neoplasm: Given that VEGF can be synthesized through Cap-dependent way and multiple alternative ways driven by the other cis-acting elements, including IRES, uORF, and G-quadruplex, resulting in occurrence of VEGF synthesis in diverse conditions including tumor-related stresses and drug treatments25,48, the depleted VEGF protein but not its mRNA abundance by CADPE serves as a typical result to verify the potent effectiveness of CADPE on Cap-dependent and alternative translations.