The effects of CADPE on both transcriptional and translational key regulators in CRC cells were investigated, including oncogenic signaling from divergent pathways β-catenin, c-Myc, NF-κB, and STAT3 (refs. 4,42) and key nodes of translation system mTOR pathways (mTOR, Raptor, Rictor, p-S6, p-4EBP), eIF4F (eIF4E, eIF4A, and eIF4G), all of which drive CRC and are associated to residual disease in solid cancers. The gene discussed is RPTOR; the disease is colorectal carcinoma.