However, eIF4F and the other pro-tumorigenic proteins were not decreased at the early time points and even at 24 h (data not shown), and CADPE did not affect the levels of eIF4A and Mcl-1 (Fig. 4e), which is consistent with a previous report that selective inhibition of eIF4A decreased Mcl-1 level in leukemia cells26. This evidence concerns the gene EIF4E and leukemia.