There are also several clinical and histopathologic similarities between the main RYR1-RM diagnostic categories of central core disease (CCD; MIM # 117000), multi-mini core disease (MmD; MIM #255320), core-rod myopathy (CRM), centronuclear myopathy (CNM), and congenital fiber-type disproportion (CFTD) [28, 29]. Here, RYR1 is linked to centronuclear myopathy.