The purification of RyR1 Ca2+ release channels in 1988 [4] and the subsequent discovery in 1991 of pathogenic RYR1 variants [5] led to the association of impaired Ca2+ homeostasis with malignant hyperthermia (MH) susceptibility (MIM # 145600) [6]. This evidence concerns the gene RYR1 and Malignant hyperthermia.