This could indicate that allergy to penicillin in children has previously been overestimated as suggested by Esposito S et al. [13] We extended the guidelines recommended by EAACI Drug Allergy Interest Group [6] by performing DC in patients with a positive SPT or specific IgE, patients who would otherwise have been regarded as allergic to penicillin. The gene discussed is IGHE; the disease is allergic disease.