The American Academy of Allergy, Asthma and Immunology (AAAI) and European Network for Drug Allergy (ENDA)/ European Academy of Allergy and Clinical Immunology (EAACI) have recommend that investigation of suspected IgE-mediated penicillin allergy includes skin testing followed by an oral challenge with a therapeutic dose in skin test-negative individuals [7]. The gene discussed is IGHE; the disease is response to penicillin.