AGT and hypertensive disorder: C57BL6/J and C57BL6/N mice are a widely used tool in biomedical research.31 In experimental hypertension, this strain serves as platform for pharmacological models, such as chronic ANG II (angiotensin II) infusion, and as the genetic background for informative transgenics (eg, International Mouse Phenotyping Consortium; www.mousephenotype.org).